After a long period of inactivity the airport was relaunched by the Province of Trapani in 2003, and now hosts several flights, mainly low-cost connections.

The airport is a base for the "37th Fighter Wing" of the Italian Air Force with the Eurofighter Typhoon, and for the "82nd CSAR" (Combat Search and Rescue) with the helicopters AgustaWestland AW139.

The airport gained international attention during Operation Unified Protector in 2011 when NATO aircraft were based there during military intervention in the Libyan Civil War.

In 2023, Rete Ferroviaria Italiana announced plans for the construction of a new railway station to serve the airport on the Trapani-Castelvetrano-Palermo line.

[15] The station, officially named "Vincenzo Florio", is expected to be operational by 2026, providing a direct 45-minute train link to Palermo Airport.