[2] The club founded, by professor Ugolino Montagna and young native Abele Mazzarese to represent the West-Sicilian town was named Unione Sportiva Trapanese.

The club's first official game came against Palermo in October 1908; the more experienced Palermitan team won emphatically, scoring 12 goals.

In 2009, chairman Vittorio Morace appointed Roberto Boscaglia as new head coach, intending to bring the club's return into professionalism; in his first season in charge, Trapani ended as runner-up behind Milazzo.

In the first campaign in the third tier, Trapani surprised everyone by topping the league against all odds; an end-of-season crisis, however, led to the Sicilians being overtaken by Spezia in the penultimate week of the season and losing a direct promotion.

In the subsequent promotion play-offs, after defeating Cremonese in the semi-finals, Trapani lost a two-legged final to fourth-placed outsiders Lanciano.

Trapani's first season return to the third tier, with Calori still in charge, saw the Granata ending in third place (behind US Lecce and Catania) and then being eliminated at the playoff stage by eventual winners Cosenza.

During the summer of 2018, Trapani's ownership announced their intention to sell the club and reduce the budget due to financial and legal issues surrounding the parent company, Ustica Lines.

Vincenzo Italiano was hired as the new head coach in place of Calori, with Raffaele Rubino as sporting director for the new season.

[4] The club ended the season in second place, and had a successful campaign in the subsequent promotion playoffs, making it to the finals against Piacenza after defeating Catania in the semi-finals.

On 5 June 2019, just a few days after the first leg of the playoff finals, the Trapani playing squad announced their intention to send their notice of default after the new ownership had repeatedly failed to pay their salaries.

[8] However, after an unfavourable season that ended with immediate relegation to Serie C, Trapani were excluded altogether on 5 October 2020 due to outstanding financial issues.