Prentice held the NCAA Division I-A record for career rushing touchdowns until it was broken by Wisconsin's Montee Ball in 2012, and again by Keenan Reynolds of Navy in 2015.
His senior year was under a new head coach, Terry Hoeppner, who installed a more open passing attack rather than relying on the running game.
On September 6, 2014, during halftime of the Eastern Kentucky game, Prentice became the fourth Miami RedHawk to have his football jersey retired.
Prentice helped lead the RedHawks to a 13–10 upset of the #12 ranked North Carolina Tar Heels, rushing for 162 yards and a touchdown.
Most of his yards came in the second half, including several carries on the last drive that led to a last-second game-winning field goal by John Scott.
His numbers were not great (82 yards on 21 carries), but he ran for a touchdown on a game-changing fake field goal that was named CNN's "play of the day."