Tres Cruces is a barrio (neighbourhood or district) of Uruguay's capital Montevideo.

Tres Cruces shares borders with Cordón to the south and to the west, with La Comercial and Larrañaga to the north, with La Blanqueada and Parque Batlle to the east, Cordón and Pocitos to the south.

In 1813, the barrio was the site of the “Congress Tres Cruces” and the issuance of the "Instrucciones del año XIII" by José Gervasio Artigas in an attempt to establish an independent government for the Liga Federal in what was then known as the "Banda Oriental" ("Eastern Bank").

The barrio is the site of the national bus terminal, a major shopping centre, and several hospitals and schools.

A giant cross and statue of Pope John Paul II is located near the obelisk, erected to commemorate his first visit to Montevideo.