[4] After losing his ride with Roush in 2018, Bayne opened Mahalo Coffee Roasters in Knoxville, Tennessee as well as starting in 2021 driving a 602 Crate Late Model on a part-time basis for his own team that he shares with his younger brother Trey Bayne in the American Crate All-Star Series presented by PPM.

In 2005, when Bayne was 15 years old, he moved to the USAR Hooters Pro Cup Series Southern Division, in which he received the highest rookie honors.

One year later, he recorded Sunoco Rookie of the Race honors after participating in the Toyota All-Star Showdown at Irwindale Speedway.

He got the pole position at the Kroger 200 at Indianapolis Raceway Park and finished 7th at that race and the Virginia 529 College Savings 250 at Richmond.

[10] After recovering from his illness, Bayne made his return to racing at the STP 300 at Chicagoland Speedway on June 4, 2011, finishing third.

He won his first Xfinity Series race at the Texas Motor Speedway on November 5, 2011, by edging out Denny Hamlin on a late-race restart.

[11] On June 9, Bayne got his second career Xfinity Series victory by winning the DuPont Pioneer 250 at Iowa Speedway after Austin Dillon's handling went away.

Bayne raced at Fontana, Phoenix in April, Charlotte in May, Nashville, Loudon, Vegas in October, and at Homestead.

The Daytona 500 win also granted Bayne eligibility for the NASCAR Sprint All-Star Race in 2011 and 2012.

The team later announced that Bayne would run the All-Star as well as the spring Talladega race with sponsorship from Camping World and Good Sam Club.

However, Bayne's illness returned after racing at Nashville Superspeedway and was hospitalized for five weeks, with his Nationwide ride being taken over by Chris Buescher, Kevin Swindell and Matt Kenseth.

Bayne's Cup Series ride for the Coca-Cola 600 was driven by Roush Fenway teammate Ricky Stenhouse Jr.

The illness was originally thought to be Lyme disease,[19] but later that same year it was announced that Bayne had been diagnosed with multiple sclerosis.

He got collected in a late-race accident involving Jeff Gordon, Reed Sorenson, Ricky Stenhouse Jr., and A. J. Allmendinger, but nonetheless finished the race on the lead lap.

After the race, Bayne was called to the Oval Office and fined $20,000 for violating a race procedure made in the wake of the Kevin Ward Jr. accident in August 2014, in which a driver must remain in their car until being permitted by officials to exit (unless fire or smoke engulf the car).

He picked up his first ARCA win at Pocono after starting first and dominating the race, and recorded another Cup Series top ten in the 2015 Coke Zero 400.

Bayne's struggles would continue, as he would finish 40th in back-to-back races at Indianapolis and Pocono, being plagued by a major lack of speed at both tracks.

The next week at Indianapolis, Bayne would be involved in a wreck with Clint Bowyer on a Green-White-Checkered attempt and finish 30th.

His strategy was first thwarted by a caution that came out as soon as he took the lead, and after slipping in the standings from a pit stop found himself running fourth again.

Bayne was about to take the lead on a restart, but got collected in an accident involving him, Ryan Blaney, Joey Logano, and a few other cars.

At Talladega in the fall, he miraculously finished 3rd after his car was damaged from a couple of late race accidents and pushed by 6 drivers on the last lap and nearly beat Ryan Newman for second.

On April 14, 2018, SB Nation reported that former RFR driver Matt Kenseth would return to the team for select races in the No.

[26] After departing Roush Fenway Racing at the end of 2018, Bayne and his family returned home to Tennessee.

In late June, the Bayne family opened the Mahalo Coffee Roasters store in Knoxville.

[28] On August 31, 2020, Niece Motorsports announced Bayne would make his Truck Series debut in the team's No.

[29] He would make his second consecutive start in the series for Niece at Richmond, replacing full-time driver Ty Majeski in the No.

[30] Bayne finished fifth at Bristol, but was disqualified when his truck failed the minimum height requirement during post-race inspection.

He has credited his faith for helping him handle both the overnight success he experienced by winning the Daytona 500 as well as the health scare that took him away from racing briefly during the 2011 season.

Bayne also attended Passion 2012 at the Georgia Dome and was recognized for his faith in front of approximately 45,000 college students during the final session of the conference.

* Season still in progress 1 Ineligible for series points (key) (Bold – Pole position awarded by qualifying time.