Tri-Cities Regional Airport (TRI) has non-stop service to Atlanta, Charlotte, Ft. Lauderdale, Orlando, and St. Petersburg/Clearwater.

Additionally, TRI manages an aggressive Air Cargo program, administers Foreign Trade Zone 204, supports and promotes U.S. Customs Port 2027, and provides trade development assistance.

The Region has both CSX and Norfolk Southern mainline railway access.

In 1999, the Tri-Cities were collectively designated as an All-America City by the National Civic League.

Since the program's inception in 1949, more than 4,000 communities have competed and over 500 have been named All-America Cities.