It borders: The first evidence of human presence in the quarter dates back to prehistoric times, when some populations settled in the area of the so-called Sedia del Diavolo and of Monte delle Gioie.

Furthermore, the area is crossed by a section of the Via Salaria, a consular road of enormous importance that connected Rome to Porto d'Ascoli, so called for the trade of salt (Latin: sal).

During the Renaissance and the following centuries, the area of the quarter housed only a few noble villas and rustic buildings (farmhouses); in one of these, on the Via Nomentana, Giuseppe Garibaldi lived at the time of the Roman Republic.

Following the Italian unification, the area of Mount Antenne was fortified with large bastions, moats and with an imposing powder keg, since its position was particularly suitable for defending the northern side of the city.

In the 1970s the area was the subject of a new building speculation, which caused the demolition of Tor Fiorenza, a 16th-century fortified farm where anemic children were brought to drink the fresh milk.

The villa was built in the mid-18th century by Cardinal Alessandro Albani – the nephew of Pope Clement XI, a refined connoisseur of antiquity and protector of artists, including Anton Raphael Mengs – to keep his collections of ancient art, chosen on the advice of Johann Joachim Winckelmann.

Thus were born the "Laboratory of Neoclassicism", in which Piranesi also operated, and an "Art Gallery", for centuries inaccessible, which houses works by Niccolò da Foligno, Perugino, Gherardo delle Notti, Van Dyck, Tintoretto, Ribera, Guercino, Giulio Romano, Luca Giordano, David, Vanvitelli.

Also in the 1950s, the scene of the chase between Aldo Fabrizi and Totò in Cops and Robbers begins at the end of Viale Somalia and continues on a hill where the future Via Olimpica was built.

The same UPIM store in 1960 is the workplace of the three protagonists of Caccia al marito with Sandra Mondaini, while in We All Loved Each Other So Much by Ettore Scola, Piazza Caprera is used to mark a change of time.

Due to its peculiar architecture, the Quartiere Coppedè was chosen by the director Dario Argento, residing in the quarter Trieste, as the background for some scenes of his movies The Bird with the Crystal Plumage (1970) and Inferno (1980).

Among all the sequences, one of the most moving images is the vision of a totally deserted Via Nomentana in the 1941 small masterpiece of De Sica Teresa Venerdì, set in the streets of the quarter.

In more recent times, the public high school "Giulio Cesare" has been the backdrop for the fiction Piper and the movie Scusa ma ti chiamo amore by Federico Moccia.