With a program rich in screenings, retrospectives, tributes, conferences and meetings with renowned international and national professionals, it aims to explore the whole range of the science fiction world, from cinema to comics, from literature to stage performances.

[3][4] In those years, the festival saw the participation of Arthur C. Clarke, Roger Corman – whose X: The Man with the X-ray Eyes was awarded the Astronave d'argento (Silver Spacecraft) in 1963 -, Riccardo Freda, Forrest J. Ackerman,[5] Umberto Eco (one of the 1963 Jury members) and Brian Aldiss, among others.

In the year 2000, La Cappella Underground decided to pick up the tradition of the festival, presenting to the audience independent film productions, premières and rarities in a new event called Science plus Fiction.

[7] Over the years the Award was bestowed to: Dario Argento (2003),[8] Jimmy Sangster (2004),[9] Lamberto Bava (2005),[10] Enki Bilal and Terry Gilliam (2006),[11] Joe Dante (2007),[12] Ray Harryhausen (2008, via videoconference from London),[13] Roger Corman and Christopher Lee (2009),[14] George A. Romero (2011),[15] Alfredo Castelli (2012),[16] Gabriele Salvatores (2013),[17] Alejandro Jodorowsky (2014),[18] Bruce Sterling (2015),[19] Rutger Hauer (2016),[20] Sergio Martino (2017),[21] and Douglas Trumbull (2018).

In 2005 Science plus Fiction became part of the Méliès International Festivals Federation,[26] a network including all the main events in the field and aiming at the promotion of the European genre production on a big scale.