Trilacoochee is an unincorporated community in the northeast corner of Pasco County, Florida, United States.
Trilacoochee is bordered by Trilby to the northwest, Lacoochee to the northeast, Blanton to the west, the Green Swamp to the east, and Dade City to the south.
In time the town gained a school, two post offices, a shingle mill, and after clay deposits were discovered in 1907, a brick yard and kiln were installed.
US 98 was extended through Pasco County in 1952, and joined US 301 in a multiplex from Trilacoochee to Clinton Heights south of Dade City.
In 1967, the ACL and SAL merged to form the Seaboard Coast Line Railroad, which brought the junction into decline.