The northern section of the riding was the Annex district, while the eastern edge contained part of the University of Toronto and thousands of students.

According to the 2011 Canadian census Average household income (2010): $86,895 Median household income (2010): $60,659 Median income (2010): $34,761 Unemployment: 7.3% Language, mother tongue (2011): English 61.2%, Chinese 13.0%, Portuguese 4.4%, French 2.8%, Spanish 2.1%, Italian 1.8%, Korean 1.4%, Arabic 1.4% Religion (2011): Christian 42.9% (Catholic 24.4%, Anglican 3.6%, Christian Orthodox 2.5%, United Church 2.5%, Presbyterian 1.3%, Other 8.3%), Muslim 4.2%, Jewish 4.1%, Buddhist 3.4%, Hindu 1.8%, No religion 42.5%.

Ethnic groups (2011): White 61.8%, Chinese 16.0%, South Asian 5.1%, Black 3.6%, Korean 1.8%, Filipino 1.8%, Latin American 1.7%, Southeast Asian 1.7%, Arab 1.6%, West Asian 1.1% It consists of the Toronto Islands and the part of the City of Toronto bounded on the south by Toronto Harbour, and on the west, north and east by a line drawn from the harbour north on Spencer Avenue, east along the Gardiner Expressway, north on Dufferin, east on Queen Street West, southeast along the Canadian Pacific Railway line, north along Dovercourt Road, east along Dundas Street West, north along Ossington Avenue, east along the Canadian Pacific Railway situated north of Dupont Street, south along Avenue Road and Queens Park Crescent West, east along College Street and south along Yonge Street to the Harbour.

This area is very strongly NDP and has a highly activist population that provides many campaign workers for the New Democrats.

As per 2012 federal electoral boundaries redistribution and the 2013 representation order, Trinity—Spadina was dissolved following the conclusion of the next general election to be called after May 1, 2014.