The Trinity Neighborhood House is a historic brick townhouse at 406 Meridian Street located in the Eagle Hill section of East Boston, Massachusetts.

[2] The building is now owned by Neighborhood of Affordable Housing, Inc. and is a 16-unit single resident occupancy (SRO) facility for the formerly homeless.

On November 19, 1957, comedian Anna Russell held a concert at Jordan Hall in Boston to benefit the House.

[4] On May 8, 1958, noted archaeologist Byron Khun de Prorok gave a fundraising lecture at the New England Mutual Hall.

[5] On February 4, 1960, a screening of the film Sweet Love Remember'd starring Margaret Sullavan was scheduled to benefit the House, but due to her untimely passing, the show was cancelled.