[8] T. melleri is relatively common in the bushy savannas and woodlands of East Africa where it can be found in Malawi, northern Mozambique, and Tanzania.

[6] Spots and broad vertical bands on the chameleon's flanks range in color from brown, dark green, yellow or even black.

When basking in the sun, the side of their body towards the sunlight can turn dark green or black, while the rest of the animal stays much lighter.

Severe stress turns the chameleon first charcoal gray, followed by pure white adorned with yellow stripes.

Like most chameleons, Meller's are strict carnivores eating insects, smaller lizards, spiders, crickets, worms, and caterpillars.

[12] Newborn Meller's chameleons are about 4 inches (10 cm) in length and must be fed Drosophilidae and tiny crickets for the first three weeks of their lives.

[5] Afterwards, they accept house flies and larger insect prey including crickets, locusts, silkworms, and cockroaches.

[13] Wild caught specimens of T. melleri have fared poorly in captivity, often imported with heavy parasite loads, they have a high mortality rate.