Initially performing as Patsy Ann Noble, she was a teenage pop singer in the early 1960s, with regular appearances on the Australian music and variety television series Bandstand.

By the 1970s, she had relocated to the United States and had guest roles on various television series including The Mary Tyler Moore Show, Columbo, Baretta, McMillan & Wife, The Rockford Files, and Buck Rogers in the 25th Century.

[5][6] Her singing career was encouraged by Brian Henderson, the compere of the Australian version of Bandstand, where she made regular appearances.

[6] There, she released many "girl group"-sounding pop songs including "Sour Grapes" (February 1963), "I'm Nobody's Baby" (1963), and "Accidents Will Happen" (1963), but received little commercial success – although she continued to score hits between 1963 and 1965 in Australia.

In the second half of the 1960s, she turned to acting and made her dramatic screen debut in a 1965 BBC television production entitled The Snowball, and soon found herself appearing on other television series, including the 1966 Danger Man episode "Not So Jolly Roger" (in which her recording "He Who Rides a Tiger" was featured), Callan (1970, "The Same Trick Twice") with Edward Woodward, and films such as Death Is a Woman (1966), in which Noble had a lead role as the femme fatale),[6] and Carry On Camping (1969).

In 1975, Noble appeared in the Columbo episode "Playback", in which she meets the murderer (played by Oskar Werner) in an art gallery wearing a low-cut dress.

In 1976–77, she had the ongoing role of Yvonne Holland on the soap opera Executive Suite,[6] and appeared in the 1977 television miniseries The Rhinemann Exchange and Testimony of Two Men.

In 1980, Noble played the role of heiress Phyllis Morley in the mystery comedy film The Private Eyes starring Tim Conway and Don Knotts.

Another ongoing role was as Detective Rosie Johnson on the police drama Strike Force (starring Robert Stack) on ABC in 1981–82.

Soon after Strike Force was cancelled, Noble returned to Australia in 1983 with her son Patrick because her father, Buster, was seriously ill.[4] She re-established a career there as a theatrical actress.

In 2003 Trisha Noble played the role of Ellie Greenwich's "Ma" to critical acclaim in "Leader of the Pack" at The Star in Sydney, showcasing both her comic onstage genius as well as her vocal range, never failing to bring the audience to tears with her stunning rendition of "Look of Love".