The river is formed by the merger of the Kyirong Tsangpo and the Lende Khola originating in Gyirong County of Tibet, which join together near the Rasuwa Gadhi on the Nepal–Tibet border.

[2] The sources of the Trishuli River lie in the Pekhu Kangri range (called Langtang Himal in Nepal) in the Kyirong County in Tibet.

[3][4] Lende Khola has two further tributaries originating in Langtang Himal, viz., Richong Chu and Chusumdo Tsangpo, the latter again forming part of the Nepal–China border.

It is called Trishuli Ganga after receiving the Trisuli Khola stream originating in Gosainkunda near Dhunche.

[7] Trisuli is Nepal’s most popular rafting river with impressive gorges, exciting rapids, some easier sections and easy accessibility from Kathmandu and Pokhara.

The curvy Prithvi Highway has led to the death of many Nepalese traveling to or returning from Kathmandu.