[6] After his sophomore season, Wirfs broke the Hawkeyes hang clean record held by Brandon Scherff, setting the new mark at 450 pounds.

[14] As a rookie, Wirfs started all 16 games in the 2020 season, playing at right tackle, only allowing 1 sack to Khalil Mack of the Chicago Bears in Week 5.

[15][16] Wirfs played and started all four games in the Buccaneers' playoff run that resulted in the team winning Super Bowl LV.

[20] Wirfs started all 17 games for the Buccaneers in 2021, before suffering an ankle injury in the Wild Card Round of the playoffs that kept him out the remainder of the season.

[21][22] After another strong year performance wise, Wirfs was named to his first career Pro Bowl and garnered a first-team All-Pro selection.

[32][16] On August 1, 2024, Wirfs and the Buccaneers agreed to a five–year, $140.63 million contract extension, a deal that made him the highest paid offensive lineman in NFL history.