1431, the son of Jean Salazar (a leader of the Écorcheurs) and his wife Marguerite, who was the daughter of Georges de la Trémoille.
He called a synod in Sens in August 1485 to confirm regulations passed by his predecessor, Louis de Melun.
In February 1499, he served as an ambassador to the Swiss Confederacy to seek an alliance in Louis XII's war against Maximilian I, Holy Roman Emperor.
During the War of the League of Cambrai, he presided over a council at Pisa in May 1511 that purported to depose Pope Julius II.
In 1479, he commissioned Francesco Florio to produce a copy of the Decretum Gratiani that is currently on display at the Bibliothèque de l'Arsenal.