[2][3] Skyler is the author of the play The Moonlight Room,[4] about at-risk youth in New York City, which she co-produced at the TriBeCa Playhouse in 2003 before transferring to a commercial run Off-Broadway on Theater Row.
Previously she co-wrote the feature film "Getting to Know You," directed by her sister, Lisanne Skyler, and adapted from short stories by Joyce Carol Oates.
The Man Who Knew Infinity tells the story of the self-taught Indian math genius Srinivasa Ramanujan, whose work is considered the foundation of the digital age.
It was screened at the White House by the Office of Science and Technology as part of an initiative on media representation of STEM fields in October 2016, and featured in the Breakthrough Prize ceremony in November 2016.
In 2015 it was announced that Skyler had co-written with Scarlett Johansson, who will also direct, an adaptation of Truman Capote's lost novella Summer Crossing which was rediscovered and published in 2005.