The station building, a landmark of the city, is located in Thampanoor opposite the central bus stand.

The station was built during the reign of Sethu Lakshmi Bayi, the maharani of Travancore, and was inaugurated on 4 November 1931.

[5] Thiruvananthapuram was a branch-line station, but the maharani built it on a par with its counterparts in India's major cities.

The Nemom and Kochuveli stations were announced in the railway budget as satellite terminals of Thiruvananthapuram Central.

The Kochuveli satellite terminal has begun operation with trains originating from Thiruvananthapuram Central.

A networked electronic surveillance system was installed by the Railway Protection Force (RPF) to improve security and monitor passengers arriving at the station.

Former Union Minister for Railways Lalu Prasad laid the foundation stone for the station's expansion and modernization in December 2006.