Set in modern-day Manhattan, the film begins with the narrator (Lemmy of Motörhead) introducing two families: the rich Capulets and the poor Ques.

In the meantime, an intense duel between Murray and Sammy Capulet catches the attention of Detective Ernie Scalus, who gathers the heads of the two families together and declares that they will be held personally accountable for any further breaches of the peace.

On the insistence of Murray and Benny, Tromeo attends the Capulets' masquerade ball in the hopes of meeting Rosie, only to find another man performing cunnilingus on her.

Now a kinsman to the Capulets, Tromeo reassures Tyrone that Juliet doesn't want Arbuckle as her husband anymore hence announcing a truce to both families.

Eventually, Murray stands by Tromeo's side to try and defend his honor but is fatally wounded by Tyrone's club as an example for anyone, besides Arbuckle, who dares to seduce Juliet.

Together, the three devise a plan to clear the Que family name and end the Capulet/Que feud for good, enlisting the help of Fu Chang, the apothecary, who sells Juliet a special potion which will aid her predicament.

After the initial shock at the revelation that they are siblings, Tromeo and Juliet brush it off as they are determined not to let their whole ordeal be for naught; they passionately embrace and drive off into the sunset.

The film picks up six years later in Tromaville, New Jersey, where Tromeo and Juliet, now married, have become suburban yuppies with a house and (birth defected/deformed) children of their own.

[4] Gunn completely rewrote the script, again in Shakespearean verse, making it darker and far more obscene;[5] the original version had Juliet as a stripper and Tromeo as a crack dealer.

I don't remember whether they ever did but this gave their on-screen scenes together terrific sexual tension and was something a sex-crazed pervert like me would never have thought of in a zillion years," Kaufman said.

Although many times more explicit than what Hollywood is permitted to show, there is something goofily exhilarating in the spectacle of all the staple images of teen-age sex and slasher movies transformed into farce.

"[10] In a review for Entertainment Weekly, J.R. Taylor gave the film a grade of B and wrote, "While this comedy about star-crossed idiots (Jane Jensen and Will Keenan) has all the kinky sex and ultraviolence expected of the Troma studio, which built its reputation on chimichangas like The Toxic Avenger, Shakespeare’s dewy tragedy still glistens amid the deep-fried glop.

"[12] Tony Howard summarized it as a film "in which Juliet and the Nurse have lesbian sex, Romeo masturbates, various body parts are removed, the feud is between rival porn czars and incest rules".

[14] After the success of Tromeo, Troma had plans to develop a spiritual sequel entitled Schlock and Schlockability (a play on Sense and Sensibility), in which Jane Austen is reincarnated as a well-endowed female who takes revenge on all of the Hollywood movie producers who have bastardized her novels.