The main station building consists of an older section in historicism brick, while the annex is in postmodernistic concrete and glass.

[3] Two daily departures serve Sweden and Storlien,[4] in addition there are three services to Røros, with connections onwards to Østerdalen.

There are several kiosks and cafés, as well as a car park, taxicabs, bicycle stands and baggage lockers.

[5][7][8] Trafikanten Midt-Norge, which sells bus tickets and provides information on public transport routes in Trøndelag, can be found in the new section.

[8] The commuter trains serve other railway stations in neighborhoods in Trondheim; Heimdal, Selsbakk, Marienborg, Skansen to the south, and Lademoen/Nedre Elvehavn, Lilleby, Leangen and Rotvoll to the east.

[12] NOR-WAY Bussekspress operates coaches to Oslo via Røros, Namsos and Bergen via Førde.

[21][22] Trondheim S is located about ten minutes walk, or a two-minute bus ride, from Pirterminalen where Fosen Trafikklag operates passenger ferries across the fjord to Vanvikan, and out of the fjord to Brekstad, Sistranda and Kristiansund.

In 1877 the state and city made an agreement to build a new station at Brattøra to serve the new Meråker Line that was being built to Sweden.

The main station in the east served all passenger trains, and was designed by the architect Balthazar Lange.

On 23 April 1888 a landslide hit the station, with 180 metres (590 ft) of track—three wide and including the main Rørosbanen line—was washed into the sea.

Instead the 92 metres (302 ft) Skansen Bridge was built on the west side of the station, along with a double track to Marienborg where the new depot would be located.

[31] The amount of trackage for cargo was increased, with a wide section of land mass being filled into the sea to create a larger rail and port facility at Brattøra, though the filling of a large part of the seabed to create artificial land.

The new depot opened in 1916, and in 1917 the double track and dual gauge to Marienborg as well as the new freight terminal was finished.

[34] The main building designed by Lange is in historicism and was originally built in two stories in brick.

In addition to the bus station it features and extension of the waiting area, offices, a restaurant and a parking lot.