[6] According to senior content designer Johannes Pfeiffer, Tropico 6 has "fully simulated" citizens, where the actions of El Presidente's government towards the citizenry can have an effect on productivity, and possibly even result in a revolt.

[22] CGM called Tropico 6 the "strongest entry in the franchise", praising its music, graphics, and writing, while recognizing the presence of minor bugs and jank, ultimately deeming the title a full realization of the series' potential.

Shacknews heavily lauded the "incredibly addictive" gameplay, crisp UI, sheer detail, variety of strategic options, and comedy, and expressed minor gripes with the repetitive music and sometimes convoluted main screen.

Foreign powers have traditionally taken a dim view to piracy, but in this, a game that specifically pokes fun at international relations, it just doesn't come up...where the missions excel, however, it's in forcing you to take actions that can upset the delicate balance of economic growth".

Nintendo Life, while reviewing this port, wrote, "Despite some irksome performance problems, occasionally inconsistent pacing and some rather rough visuals, the game is a lot of addictive fun to play and its cheerful ambiance and compelling systems will keep you glued to your handheld".