In August 2005, Lesesne signed with the Charleston Battery where he made 38 appearances in two seasons and helped the team progress to the United Soccer League Championship semifinals in 2006.
From 2005 to 2014 Lesesne spent ten years as an Assistant Coach for the College of Charleston where he helped the program compile an 82–76–14 record, along with a Southern Conference regular-season championship and a second-round National Collegiate Athletic Association Tournament appearance in 2010.
In 2015, Lesesne was named the first assistant for the new expansion United Soccer League Championship team, Charlotte Independence, where he spent four years coaching under Mike Jeffries.
Lesesne also played an integral role in helping New Mexico United establish the Diversity Fellowship Program and a fully-funded youth academy, which produced its first-ever homegrown signing in Cristian Nava in 2021.
[5] On November 14, 2023, it was announced that the Red Bulls would not be renewing Lesesne's contract, rather looking for coaches that maximize the change in approach with their youth players.