He played as a cornerback for the Miami Dolphins, the Philadelphia Eagles, the Buffalo Bills and the Washington Redskins of the National Football League (NFL).

[8] He finished his collegiate stint with 192 tackles, four interceptions and three punts returned for touchdowns, and was named team captain and MVP in his final season.

[14] Prior to the 2004 NFL season, Vincent signed a free agent contract with the Buffalo Bills with the departure of cornerback Antoine Winfield.

[15] On November 5, 2006, against the rival Dallas Cowboys, Vincent recorded six tackles and had a crucial block on a 35-yard field goal attempt by kicker Mike Vanderjagt as time expired.

The block, along with a 15-yard face mask penalty, allowed the Redskins to return the ball into field goal range for kicker Nick Novak and win the game 22–19 with no time.

The annual award recognizes Big Ten football student-athletes who have garnered significant success in leadership roles following their academic and athletic careers.

[25] In an October 24, 2017, feature article in The Root publication, Vincent discussed his role as "bridge-builder" in the ongoing debate about players taking a knee during the playing of the national anthem.

[31] He has described flag as "football for all" due to the sport's greater accessibility for women, people with disabilities, and others to play in a non-contact format and earn opportunities such as college scholarships.

[21] During his tenure as head of development and engagement, Vincent expanded the league's services, helping to launch programs such as NFL Total Wellness for current and former players.

It is alleged Vincent emailed this information to his longtime business partner Mark Magnum for the benefit of a financial services firm co-owned by the two men.

[45] However, the Associated Press uncovered no evidence to support the contention that Vincent, by forwarding an NFLPA e-mail to his business partner, used agents' personal information to build his financial services company.

[46] While playing for the Buffalo Bills, Vincent approached the Wharton School with an idea to create educational programs to help fellow players prepare for life after football.

Jason Wingard of the New York Daily News[47] spoke to Vincent's vision and the need for those entering the NFL to prepare for retirement from football.

[57] Vincent has been honored by organizations such as Womanspace, Women Against Abuse and the Joe Torre Safe at Home Foundation for his work to advance domestic violence awareness.

[58][59][60] Vincent and his family founded the Love Thy Neighbor Community Development and Opportunity Corporation, a not-for-profit organization dedicated to fostering positive change in young people's lives through character, athletics and academics.

[62] Each year ahead of the Super Bowl, Love Thy Neighbor holds a virtual fundraiser and the "Vincent Country Safe Zone Activity Day" for students at an under-resourced elementary school in the game's host city.

The seventh annual activity day in 2024, held at Matt Kelly Elementary School in Las Vegas, Nevada, included sports, games, food and resources.

Students received free eye exams and glasses, health screenings, and haircuts provided by former NFL star Steven Jackson, co-founder of the Original Barber School in Las Vegas.

His son Taron Vincent is a defensive tackle who played college football at Ohio State[67] and signed with the Los Angeles Rams in 2023.