Shin'ichirō has known Hiromi for years, but before he had always treasured her smile, though now she acts coldly when at home and he cannot bring up the nerve to talk with her either.

At school, he meets a strange girl named Noe Isurugi who wishes him misfortune after Shin'ichirō teases her.

After a bit of bad luck, he reconciles with Noe by crafting a chicken out of a tissue box, and he finds out from her that she "gave her tears away".

The opening video of the anime contains shots of the Tateyama mountain range in Toyama Prefecture, Japan, and is where the series is set.

The anime shares its title with the visual novel True Tears by La'cryma, but uses an entirely different story with different characters, and a different art style.

[4] A Blu-ray box set released in Japan contains an extra three-minute epilogue to the series unveiling the future of the main characters after the anime's conclusion.

"Tears of the World"), and the insert song, used in episode ten, is "Sono Mama no Boku de" (そのままの僕で) by Eufonius.

It has three hosts — Ayahi Takagaki, Kaori Nazuka, and Yuka Iguchi, who played Noe Isurugi, Hiromi Yuasa, and Aiko Endō in the anime respectively — and was produced by Bandai Visual and Lantis.