The film centers around four best friends: Married couple Tom and Rebecca and longtime relationship partners Tobey and Elaine.

Rebecca, a film actress making her stage debut, meets a younger actor named Jasper, who shows infatuation for her.

Trust the Man premiered at the 2005 Toronto International Film Festival[2] and was picked up by Fox Searchlight Pictures for distribution in North America, Argentina, Paraguay, Uruguay, Chile, the Benelux, China, Colombia, France, Hong Kong, India, Japan, Mexico, South Korea, Switzerland and Taiwan.

The website's critics consensus reads: "What aspires to be a sophisticated, unconventional romantic comedy turns out to be a contrivance-filled pretender to other, better films of its genre.

"[8] Liz Beardsworth of Empire gave the film 3 out of 5 stars and wrote "Freundlich’s retread gleans new colour thanks to his sparkling dialogue, the urbane New York setting and great work from his superior cast, all of whom flesh out their roles so that empathy with their respective plights comes easily.