The tobacco industry agreed to pay the states billions of dollars in perpetuity, making the MSA the then-largest civil litigation settlement in U.S. history.

[11] In 2018, the Truth Initiative partnered with Office of National Drug Control Policy and the Ad Council to combat opioid addiction.

[16] Researchers in the Truth Initiative Schroeder Institute publish dozens of peer-reviewed research articles each year with the goal of identifying methods to minimize the harms of tobacco use, measure the effectiveness of interventions and identify best practices for tobacco control.

[17] Research is also done to assess the Truth campaign's efforts, both pre-and post-market, including the use of the longitudinal Truth Longitudinal Cohort (TLC) survey of more than 10,000 young people and a continuous tracking study to assess campaign awareness and message receptivity.

[18] In the early 2000s the American Legacy Foundation (as the Truth Initiative was then known) gave around $10 million of the settlement funds it managed to the University of California San Francisco (UCSF) to help it formalize and expand the collection of internal tobacco industry documents that its library already hosted; the collection was then named the Legacy Tobacco Documents Library.