The population of Tsaritsani is occupied in animal husbandry, agriculture (mainly grain, vegetables and tobacco) and winery.

[6] The settlement is recorded as a village and with two names first as "Kiliseli" and as "Çerniçani" in the Ottoman Tahrir Defter number 101 dating to 1521.

[6] The first guerilla groups of the Greek People's Liberation Army in the area were created from residents of Tsaritsani.

The village witnessed mass execution of its people twice, on 12 March 1943 and on 20 August 1944 by the Italian and German occupation forces respectively.

Greek international footballer Giorgos Mitsibonas, a Tsaritsani native, started his career from the club.