Tsugaru Nobuhira (津軽 信枚, May 9, 1586 – February 14, 1631) was the second daimyō of Hirosaki Domain in northern Mutsu Province, Honshū, Japan (modern-day Aomori Prefecture).

As a reward for his services at the battle of Sekigahara, the clan was given only a nominal 2000 koku increase in kokudaka with an estate in Kōzuke Province.

An O-Ie Sōdō placed the domain in danger of attainer, but the issue was resolved through the arbitration of the Tokugawa shogunate giving Nobuhira the title of daimyō.

The completed castle, with its huge five-story donjon was on a scale far larger than typical for a 47,000 koku daimyō.

In September 1627, a lightning strike set the five-story donjon of Takaoka Castle on fire, which caused a warehouse filled with gunpowder to explode.

He took steps to increase the rice production in his province by developing new paddy fields, irrigation, and by bringing in craftsmen and artisans from other parts of Japan.