Construction on the current Tucson High School Main Building began in 1923 and was completed in 1924, in time for the fall classes.

The grand building with its ornate details, such as Corinthian columns, stood as an architectural masterpiece then and remains the same today.

[15] Noteworthy programs at THMS include performing and visual arts; technological education providing comprehensive curriculum to all students with the most current technology available in these areas; an integrated program in humanities, arts, math, science, computers, bilingual and block English/social studies classes; the unique location enables students to take advantage of programs at the University of Arizona, Pima Community College, and the Downtown Arts District; award-winning marching band and jazz ensembles; vocal music; orchestra; mariachi; guitar; musical theater; folklorico; piano lab; film acting; studio photography; commercial arts; steel drums; environmental biology; integrated technology; robotics; and desktop publishing; and advanced placement classes are available in ten academic areas.

[17] This program's curriculum is specifically designed to give Chicano/Latino students a more inclusive and culturally aware approach to education.

Started in 1919 as instrumental music by Arthur Sewell[18] the program has grown immensely in its 100+ year time.

[36] The program was handed off to a former student, Reuben Woodruff in 2021 before being taken over by band director Morani Sanders that same year.

[39] Obtaining magnet status in 1982, Tucson High boasts four areas of specialized study: Visual and Performing Arts, Science, Mathematics and Technology.

Magnet programs in the Tucson Unified School District were established in compliance with a desegregation lawsuit.

Tucson High's Main Building was constructed in 1924[41] and was designed by famous architect Henry O. Jaastad.

It has been placed on the National Register of Historic Places in Washington, D.C.[42] Second Avenue once ran North and South in front of the Main Building on the West side, and 7th Street once ran East and West along the South side of the Main Building before the campus expanded and eliminated these through streets, an area now known as “The Mall”.

The E-Wing also has a tunnel that connects it directly to the back of the auditorium, allowing music students to quickly get on stage for performances.

The back wing is used to hold technical classes (i.e. Welding, Machinery, Auto Shop, and Computer Management).

The Majority of the schools Visual and Performing Arts Classes are held in the western end of the Tech Building as well as the Tucsonian Yearbook and Cactus Chronicle Publication workrooms.

The majority of the schools Math and Science classes are located in the Tech Building's eastern end.

1939: Designed by Roy Place,The Physical Education Annex, including a gymnasium, is built to replace the existing gym on the third floor of the main building.

The current facility was built in 2008 replacing original ball park from 1947 and added flood control basin.