The station was built and firstly operated by the Buenos Aires and Rosario Railway (BA&R) and then added to Ferrocarril Mitre network in 1948.

In Tucumán station passengers transferred Ferrocarril Central Norte trains that allowed them to reach Northern provinces of Salta and Jujuy.

The CAR also ran several express services to the North of Argentina, being the Estrella del Norte (inaugurated in 1914) the most famous train that joined Buenos Aires and Tucumán.

[4] After TUFESA was dissolved, trains to Buenos Aires would be run by NOA Ferrocarriles S.A.,[5] with a service named El Jardín de la República ("Garden of the Republic"), taking about 24 hours to connect both cities.

[7] In November 2014, the Government of Argentina (through the State-owned company Trenes Argentinos S.A.) took over the services to Rosario, Santa Fe, San Miguel de Tucumán and Córdoba, leaving Ferrocentral inactive.