Despite being found in geographic locations similar to those of 'true' river dolphins such as the boto, the tucuxi is not closely related to them genetically.

Physically, the species resembles the bottlenose dolphins, but differs sufficiently to be placed in a separate genus, Sotalia.

The tucuxi exists along much of the length of the Amazon River and many of its tributaries, and is found in Venezuela, Brazil, Peru, Ecuador, and southeastern Colombia.

Thirty species of fish are known to be prey, some living in protected lakes and channels, while others occur in fast-flowing rivers.

Tucuxis are quite active and may jump clear of the water (a behavior known as breaching), somersault, spy-hop or tail-splash.

[12] The oil and fat in the skin of tucuxi is used in local traditional medicine as an ointment to be rubbed on wounds or sore body parts.

[13] The eyes, teeth, and genital organs of tucuxi are sold throughout Northern Brazil as magical charms that promote good luck, love, and financial rewards.

The number of dolphins harvested for magical or religious purposes and its effect on tucuxi populations is unknown.

[14] The tucuxi's habitat has been greatly affected by anthropogenic activities including the expansion of hydroelectric projects, which usually results in isolation where a dam is built.

[13] Pollution from human activity has also degraded the quality of the habitat and increases the chance for tucuxis to consume heavy metals.