After Trajan's Dacian Wars at the beginning of the 2nd century AD, the city was included in the Moesian Limes defensive frontier system as a military fort and port for a detachment of the Classis Flavia Moesica.

During the 4th-5th centuries, the city still preserved its military statute (headquarters of cuneus equitum armigerorum, praefectus ripae legionis primae ariae cohortium quinque pedaturae inferioris).

In 1853, The Times of London noted that "Toultcha" was "the last fortified place held by the Turks on the Danube, and which has a garrison of 1,200 men.

"[8] During the Russo-Turkish War of 1877–1878, Northern Dobruja and specially Tulcea would be the sites of massacres and conflicts between Muslim Circassians and Christian Bulgarians, Russians, and Ukrainians.

The Circassians of Dobruja had settled there in 1864 after the Circassian genocide, and through their raids to other peoples of the region and handing over part of their gains to the Ottoman authorities, they would end up indirectly financing the construction of buildings that still stand in Tulcea today: the modern Tulcea Art Museum and the Azizyie Mosque.

Tulcea was occupied by the Central Powers between 1916–1918 during World War I, and became part of their condominium following the Treaty of Bucharest in May 1918 (until November 1918).

[12] At the 2021 census Tulcea had a population of 65,624 with a majority of Romanians (74.83%) with minorities of Lipovans (1.9%), Roma (1.57%), Turks (0.67%), Ukrainians (0.42%), Greeks (0.27%), Bulgarians (0.03%), others (0.38%) and unknown (19.93%).

At the 2011 census Tulcea had a population of 73,707 with a majority of Romanians (83.37%) with minorities of Lipovans (2.36%), Roma (1.29%), Turks (1.11%), Ukrainians (0.51%), Greeks (0.28%), Bulgarians (0.02%), others (0.53%) and unknown (10.53%).

Named in honor of the conductor George Georgescu (1887–1964), an important figure in the development of Romanian classical music who was born in the Tulcea county, the contest was at first open only to Romanian music school and high school students but began admitting international students in 1995.