Tuipulotu grew up in Hawthorne, California and attended Lawndale High School.
He was rated a three-star recruit and committed to play college football at USC over offers from California, Utah, Washington, and Stanford.
He finished the season with an FBS-leading 13.5 sacks, and was named a finalist for the Bednarik, Nagurski, and Hendricks awards.
Tuipulotu was selected by the Los Angeles Chargers in the second round, 54th overall, of the 2023 NFL draft.
[12] He is also a cousin of former USC and current San Francisco 49ers defensive back Talanoa Hufanga.