In 1712, after having served in several minor positions in the Qing government, the Kangxi Emperor appointed him to the Qing embassy to Ayuka Khan (r. 1673-1724) of the Torghuts, who had migrated to the lower Volga River, where they had formed the Kalmyk Khanate under Peter I of the Russian Empire.
This fascinated many readers in Europe, and later appeared in English, German, Russian and French translations.
In 1727, Tulišen served as head of the Qing delegation when the Treaty of Kyakhta was negotiated with the Russian representative Savva Lukich Vladislavovich-Raguzinsky.
However, upon his return to the capital Beijing, he was accused of misconduct during the treaty negotiations as well as having betrayed military secrets earlier in his career.
Following the enthronement of the Qianlong Emperor in 1735, Tulišen was given a number of important positions in the government, but was later forced to retire because of failing health.