Tullis-Toledano Manor, also known as, the Toledano-Philbrick-Tullis House, was a red-clay brick mansion on the Mississippi Gulf Coast in Biloxi.

Christoval Sebastian Toledano, a sugar and cotton broker of Spanish descent from New Orleans, built the house in 1856 for his second wife, Matilda Pradat.

Another structure on the property was a two-story brick kitchen with servant's quarters located approximately 50 yards (46 meters) behind the main house.

[4] After weathering 150 years of storms from the Gulf, Tullis-Toledano Manor was completely destroyed during Hurricane Katrina on August 29, 2005.

The name was derived from local legend that native Indian tribes and French colonials signed treaties under the oak's branches.