He is best known for his appearances with Jim Crockett Promotions and the World Wrestling Federation in the mid-to-late 1980s as a member of The Four Horsemen and The Brain Busters.

Blanchard attended West Texas State University, where he played American football, first as a quarterback and then as a defensive end, alongside fellow future wrestlers Tito Santana and Ted DiBiase.

In the mid 80s Tully Blanchard had a series of matches with World Wrestling Council (WWC) Universal Champion Carlos Colon in Puerto Rico and the Continental United States.

On July 21, 1985, Blanchard defeated Magnum for the U.S. Championship by punching him with a foreign object in his hand given to him by Baby Doll, who came to ringside dressed as a security guard.

The feud culminated at Starrcade '85 during a brutal and extremely bloody "I quit" match held inside of a steel cage for the title.

The match ended with Magnum driving a piece of a broken wooden chair into Blanchard's forehead, which was already deeply cut and bleeding profusely, forcing him to submit.

In late 1985, Blanchard fired Baby Doll as his manager, slapping her during an interview segment and ignited a feud with Dusty Rhodes, who came to her aid.

The Horsemen feuded with the top baby faces of the territory including Magnum T. A., Nikita Koloff, Dusty Rhodes, Wahoo McDaniel, The Rock 'n' Roll Express, and The Road Warriors.

The new duo defeated Anderson and Blanchard on March 27, 1988, though they would lose the titles back to them a little more than a month later after Windham turned on Luger and became the newest Horseman.

After clashing with Jim Crockett and booker Dusty Rhodes about their pay, Blanchard and Arn Anderson left the NWA for the World Wrestling Federation (WWF) on September 10, 1988, losing in an 11th-hour title change to the Midnight Express tandem of Bobby Eaton and Stan Lane after a brief feud.

As a result, the WWF pushed a break up angle between Heenan and the Brain Busters on the November 25, 1989 Saturday Night's Main Event XXIV (taped October 31, 1989).

Blanchard debuted in the Minneapolis, Minnesota-based American Wrestling Association (AWA) in March 1990, aligning himself with The Destruction Crew.

One year later, at Slamboree 1994, Blanchard appeared with WCW for a single night, wrestling Terry Funk to a double disqualification.

On the March 31, 2008, edition of WWE Raw, Blanchard reunited with Arn Anderson, J. J. Dillon, and Barry Windham to salute the recently retired Ric Flair.

On April 27, 2016, Blanchard appeared alongside Ric Flair and Arn Anderson in an episode of Table For 3 on WWE Network, where the three former members of the Horsemen discussed their lives during and after their years as a team.

Blanchard made a surprise appearance during a sit down interview with Jim Ross and Shawn Spears on AEW's "Road to All Out" YouTube series that premiered July 17, 2019.

[4] It was announced the following day that Blanchard had signed a multi-show deal to serve as an "exclusive advisor" for Shawn Spears in All Elite Wrestling.

[6] At Full Gear, Blanchard helped Spears defeat Joey Janela by delivering an assisted piledriver on the concrete.

[7] Blanchard officially aligned with FTR on August 22, leading Dax Harwood and Cash Wheeler to defeat Kenny Omega and Adam Page for the AEW World Tag Team Championship at All Out.