He has directed some iconic Nepali films like Kusume Rumal (1985), Lahure (1989), Deuta (1991), Chino, (1991) Dakshina (1994), Balidaan (1997) and Darpan Chaya (2001).

In addition to being a film director, Tulsi Ghimire has also been a screenwriter, editor, cameraman, actor and lyricist.

Ghimire initially moved to Mumbai from Kalimpong in 1974 to work in the Indian film industry, Bollywood.

His mentor and Bollywood editor Kamlakar Karkhanis advised him to make Nepali movies at that time.

Among his movies, Kusume Rumal, Lahure, Deuta, Chino, Balidaan, Dakshina and Darpan Chhaya are considered superhits.