Nearby are the park's visitor center and the Tumacácori Museum in a historic Mission Revival style building.

The Guevavi and Calabazas missions are not open to the general public, but can be visited on reserved tours led by park staff.

Mission San José de Tumacácori was established in 1691 by Jesuit padre Eusebio Kino in a different nearby location.

After the Pima rebellion of 1751, the mission was moved to the present site on the west side of the Santa Cruz River and renamed San José de Tumacácori.

Restoration and stabilization efforts began in 1908 when the site was declared Tumacácori National Monument by President Theodore Roosevelt.

Designed by Scofield Delong, it contains interpretative displays relating to three historic missions preserved within the park,[9] and includes artwork created by artist Herbert A.