The United States has maintained official representation in Tunis almost continuously since 1795, and the American Friendship Treaty with Tunisia was signed in 1797.

Believing the U.S. knew about the attack, and was possibly involved, Tunisia considered suspending diplomatic ties with the U.S. but did not do so, after the U.S. explicitly dissociated itself from the actions of Israel.

A 2024 Pew Research poll shows that 93 percent of Tunisians are dissatisfied with the way U.S. President Joe Biden is handling Israel's war in Gaza.

The best prospects for foreigners interested in the Tunisian market are in high technology, energy, agribusiness, food processing, medical care and equipment, and the environmental and tourism sectors.

[citation needed] As of February 2008, the principal U.S. Officials included: the Ambassador Robert F. Godec, Deputy Chief of Mission Marc Desjardins, Political/Economic Counselor Dorothy C. Shea, and Commercial Attaché Beth Mitchell.

In June 2009, Gordon Gray III was named the next Ambassador to Tunisia from the United States, and served from August 2009 to July 2012.