[4] After the end of his playing career he was appointed as head coach of Tapiolan Honka and was an assistant with Finland U15.

[13] Iisalo repeated as the Bundesliga Coach of the Year in the 2022–23 campaign, after leading Bonn to a regular season record of 32 wins and two losses.

[17] On June 29, 2023, Paris Basketball of the French LNB Pro A and the EuroCup announced the appointment of Iisalo as head coach on a three-year deal.

[20] On 18 February 2024, Iisalo and Paris won the 2024 LNB Pro A Leaders Cup title, by beating Nanterre 90–85 in the final.

[24] On 13 May 2024, Iisalo was named the Coach of the Year in LNB Pro A, after leading Paris to the record streak of 25 consecutive games unbeaten.

[29][30] On 7 November, he debuted as a head coach due to absence of Taylor Jenkins, leading the Grizzlies to a 131–114 win over the Los Angeles Lakers.

[31] According to reports, the Iisalo style has been based on pace, many three-point shots and strong offensive rebounding.

Their older sister Meri Valkama [fi] became a journalist who won the 2021 Helsingin Sanomat literature prize for the best debut novel in Finland with her book "Sinun, Margot", where she tells the story of a family in East Berlin.