[2]: 88 His father appointed him to head the Inca army before his reign as emperor, granting him the title of Auqui, or crown prince, at a young age.

Topa Inca launched multiple large-scale expeditions to the north during his period as Auqui, subduing regions such as Hatun Xauxa, the Bombon Plateau, and Huaylas.

He extended the realm along the Andes through modern Ecuador,[3]: 144  and developed a special fondness for the city of Quito, which he rebuilt with architects from Cuzco.

He imposed rules and taxes, creating two Suyuyoc Apu (Governor Generals), one in Jauja and the other in Tiahuanaco.

The fortress Saksaywaman, established by Pachacuti on the high plateau above Cusco, was constructed throughout Topa Inca Yupanqui's reign.