Katari and his wife Bartolina Sisa set up court in El Alto and maintained the siege from March to June and from August to October.

In mid-September, another cousin of the Inca rebel leader, Miguel Bastidas Túpac Amaru, arrived to help prosecute the siege before it was finally broken by Spanish loyalists led by Josef Reseguín on October 17, 1781.

[9] As part of the uprising, Túpac Katari formed an army of forty thousand men and surrounded twice for a time, in 1781 the Spanish city of La Paz.

The rebels besieged the city of La Paz from March 13, 1781, for one hundred and nine days without success, due to resistance and the support of troops sent from Buenos Aires.

In this context, Viceroy Agustín de Jáuregui took advantage of the low morale of the rebels to offer amnesty to those who surrendered, which gave many fruits, including some leaders of the movement.

Túpac Katari, who had not accepted the amnesty and went to Achacachi to reorganize his dispersed forces, was betrayed by some of his followers and was captured by the Spanish on the night of November 9, 1781.

[13] For his effort, his betrayal, defeat, torture and brutal execution, Túpac Katari is remembered as a hero by modern indigenous movements in Bolivia, who call their political philosophy Katarismo.

"[14] In Argentina, as part of the Bicentennial celebrations, a Gallery of South American Patriots was inaugurated on May 25, 2010, in which Bolivia is represented by portraits of Túpac Katari, Pedro Domingo Murillo and Bartolina Sisa.