Tupambaé is a village (pueblo) in the Cerro Largo Department of eastern Uruguay.

The railroad track Montevideo - Melo pass through the south part of the village.

Its closest populated place is Santa Clara de Olimar of Treinta y Tres Department, located 21 kilometres (13 mi) to the southwest along Ruta 7.

Its status was elevated to "Pueblo" category on 19 August 1926 by the Act of Ley Nº 7.984.

This article about a place in Cerro Largo Department is a stub.