The tournament was originally scheduled to take place from 27 September to 3 October 2021, but the World Snooker Tour postponed it until March 2022 due to the COVID-19 pandemic and the 2021 Turkey wildfires.

WPBSA chairman Jason Ferguson stated that although he was disappointed by O'Sullivan's decision, the governing body had to maintain a level playing field and would not offer players extra money to appear in tournaments.

A breakdown of prize money for the event is shown below:[10] Robert Milkins arrived intoxicated at the tournament's opening ceremony, held at the Nirvana Cosmopolitan Hotel on 6 March, after drinking heavily to celebrate his birthday.

He had verbal altercations with other players and hotel guests, attempted to punch WPBSA chairman Jason Ferguson, fell and cut his chin in the toilets, and was taken to hospital by fellow professional Jimmy Robertson, where he had his stomach pumped.

[12][13][14] At a disciplinary hearing, Milkins accepted that he had brought the sport into disrepute with his behaviour and breached his player's contract with World Snooker Ltd.

[15][16] Milkins later disclosed that he had received counseling after the incident through footballer Tony Adams’ mental health charity Sporting Chance.

[11] In the round of 64, John Higgins made two century breaks, including a 128 in the final frame, to defeat the EBSA European Under-21 Snooker Championships winner Dylan Emery 5–2.

After the interval, Ding produced a run of 255 points without reply, including breaks of 73, 105, and 100, and then won a scrappy eighth frame on the pink to defeat Wilson 5–3.

Oliver Lines defeated Yan Bingtao in a 45-minute deciding frame to reach the first ranking quarter-final of his career, while Carter whitewashed Sam Craigie 5–0, including a break of 135.

Selt led by 56 points in the sixth frame, but missed key reds, allowing Ding to level the scores with a 90 clearance.

Murphy had a chance to make a winning clearance in the fourth but missed a pot on the final red along the top cushion, allowing Trump to level at 2–2.

After the mid-session interval, Trump won four consecutive frames, capitalising on missed shots from Murphy, to win the match 6–2 and reach his 35th ranking final.

The players scored a combined 189 points in the frame, just three short of the all-time professional record of 192 set by Peter Lines and Dominic Dale in 2012.

Trump said afterward that he hoped his performance in the final would foster greater Turkish interest in the sport and inspire some children to take up snooker.

Trump had been 17th on the list before the Welsh Open, but reaching the final of that tournament and winning the Turkish Masters moved him up to fourth place.

Four players withdrew from the tournament before the qualifying round had been completed: Robbie Williams,[37] Noppon Saengkham,[38] Mark Selby,[39] and Neil Robertson.

[40] Originally matches involving the top four seeds and two local Turkish players Ismail Türker and Enes Bakırcı were to be held over and played at the main venue.

[44][45] However, the 2023 Turkish Masters – which was scheduled to take place from 13 to 19 March of that year – was cancelled, because the local promoter could not guarantee adequate funding for the event.