Turweston is the most northwesterly parish in Buckinghamshire: the Ouse here forms the county boundary with Northamptonshire to the north and west and Oxfordshire to the south.

[2] In the 11th century in the reign of Edward the Confessor Wenesi, the king's chamberlain, held a manor of five hides at Turweston.

[5] Many of its rooms and passages have 17th-century oak panelling, there are three 17th-century fireplaces and a late 17th-century staircase with carved balusters.

[4] In the middle of the 13th century the chancel was rebuilt with Early English Gothic lancet windows and piscina.

[6] The south aisle was added at the same time, and its surviving Early English details are a piscina[8] and a lancet west window.

[4] The south aisle's two-bay arcade was originally in the Transitional style between Norman and Early English.

[6] In the 14th century in the chancel the lancet window on the south side was extended downwards to form a sedile and an ogeed and crocketted tomb recess was inserted in the north wall.

[4][6] On the south side are late 15th-century 9-inch (230 mm) brass figures of Thomas Grene in civilian dress with his first and second wives, Joan and Agnes.

The most notable is a Jacobean one on the east wall of the north aisle, which has kneeling effigies of Simon Heynes (died 1628) and his wife with their baby, framed by Corinthian columns.

[4][6] The stained glass in the east window of the south chapel was made by Thomas Willement in 1851.

[18] In the late 1840s the Buckinghamshire Railway's line between Verney Junction and Banbury Merton Street was built along part of the Ouse valley through the southwest of the parish, passing about 1 mile (1.6 km) south of the village.

In the late 1890s the Great Central Main Line from Manchester and Sheffield to London Marylebone was also built through the southwest of the parish, passing about 1⁄2-mile (800 m) west of the village.

Much of Turweston lies within 300 yards (275 metres) of the railway's path and this has brought property blight to the village and surrounding area.

This issue was featured in an episode of the BBC consumer programme "Rip Off Britain" in October 2014, and a zero value rating placed upon the Old Post Office in Turweston, a Grade II Listed Building.

[citation needed] East of the village is Turweston Airfield, which spans the parish's eastern boundary with Biddlesden.