[3] At the start of the series, Ginji Kusanagi (草薙 銀次, Kusanagi Ginji), a high school student on the verge of making his professional debut as a boxer, is killed in a suspicious motorcycle accident on his way to his first date with Minako Sasebo (佐瀬保 美奈子, Sasebo Minako), the girl of his dreams.

An angel (who is depicted as a Buddhist monk with cherub wings and halo) tells Ginji that because of a celestial mistake, he can be reunited with Minako, but only if he lives out the natural lifespan of another animal, after which he will return to his human body.

In the final arc, Minako is kidnapped by a murderous criminal named Kurosaki and Ginji goes and rescues her, but at the cost of losing his ability to fully reincarnate.

[7] Tuxedo Gin has been reviewed as having the sort of wacky premise and serious plotlines that make a good romantic comedy, unfortunately being weakened by mediocre characters.

Tokihiko Matsuura's art has been praised for clean lines and clear layouts but criticized for its generic character designs.