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[1] In the program, two teams of two contestants are given twelve questions to answer with the help of reference books and, in more recent editions, Dutch Wikipedia.

The first letter of each answer forms an anagram the contestants must unscramble to find a twelve-letter word.

Bonuses are awarded afterward based on the number of correct answers offered, with the highest scoring team winning the game.

[2] Questions are presented on myriad subjects in a variety of ways, with many using stock footage, and some being accompanied by animations produced by students at HKU.

A team that has won two games may choose to leave the program and receive their score multiplied into Euro (or Dutch guilder, prior to 2002); a team that wins three games retires from the show and automatically receives money for their total score.

[7] The program's success has resulted in the catchphrase Dat zoeken we op (English: 'We'll look it up') entering the Dutch lexicon.

Astrid Joosten on the show's set in 2017.