The plot is semi-autobiographical and follows "a queer black girl, Hattie, and her two straight best friends, Marie and Nia, who spend most of their days talking 'ish' and chasing their dreams."

[6] The scripted comedy series follows a queer black woman in her twenties, Hattie (Jonica T. Gibbs), and her two straight best friends, Marie (Christina Elmore) and Nia (Gabrielle Graham), as they try to find their footing in life, love, and the professional world in Los Angeles.

[3] Of her experience filming Twenties, Waithe stated that BET gave no notes and was supportive of the producers' creative vision.

[32] It received a 93% rating on Rotten Tomatoes and is described in the critics consensus, "sharply written and hilarious relatable, Twenties is another impressive series from creator Lena Waithe that also announces Jonica T. Gibbs as a talent to watch.

In a review for Variety, Caroline Framke wrote, "In large part thanks to Gibbs' appealingly loose performance, it's entertaining to watch Hattie figure out how to break into the business, but without any clear motivations pushing her, it's frustratingly ephemeral.