The moderator was sportscaster Bill Slater, who opened each session by giving the clue as animal, vegetable, or mineral.

Slater was succeeded at the beginning of 1953 by Jay Jackson, who remained through the final broadcast, and there were two changes in the panel's juvenile chair.

When McGuire graduated from high school, his decision to attend the North Carolina–based Duke University meant he could no longer remain on the program, so he asked his high-school friend Johnny McPhee to replace him.

When McPhee graduated he was succeeded by Dick Harrison (real name John Beebe) in September 1953, replaced in early 1954 by 22-year-old Bobby McGuire, appearing as the "oldest living teenager" until the end of the run.

Beginning on November 26, the series went nationwide on NBC until December 24, after which it remained dormant until March 17, 1950, when it was picked up by ABC until June 29, 1951.

The pilot featured four celebrities: actress Kelly Garrett, movie critic Gene Shalit, comedian Anne Meara, and actor Tony Roberts, along with two contestants who competed against each other.