Twin Buttes is a populated place on the east flank of the Sierrita Mountains approximately twenty miles south of Tucson, in Pima County, Arizona, United States.

Much of the actual town site is now buried underneath mine tailings, and all that remains is the Twin Buttes Cemetery.

After struggling for years to develop a few small prospects, they convinced Mayor David Stuart Rose of Wisconsin and a number of other investors to take over the property, resulting in the establishment of the Twin Buttes Mining & Smelting Company in 1903.

The town of Twin Buttes had a population of about 300 at its height, and consisted of a bunkhouse, an assay office, a company store, a butcher shop, a boarding house, and a school (run by School District No.

That year work was completed on the Twin Buttes Railroad, which connected the town with the Southern Pacific's Tucson–Nogales line at nearby Sahuarita.